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Phenotypes Associated with This Genotype
Genotype
MGI:2180006
Allelic
Composition
Sox17tm1Ysk/Sox17tm1Ysk
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Ysk mutation (0 available); any Sox17 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
• at E9.5, the foregut was small in size and deficient of endodermal cells; definitive gut endoderm was absent from the lateral region of the embryonic gut
• at E9.5, the hindgut has regressed to a cord-like structure containing significantly fewer endodermal cells
• at E9.5, the midgut has degenerated into a cord-like structure

embryo
• embryos did not exhibit axis rotation
• at E8.25, cells in the lateral region exhibited an abnormal morphology consistent with visceral endoderm
• the endodermal layer was not separated from the mesothelium by a layer of splanchnic mesenchyme
• growth and morphogenesis of the posterior trunk was disorganized after E9.5
• at E8.0, the definitive endoderm was reduced at the posterior and lateral regions


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory