Phenotypes Associated with This Genotype

Genotype
MGI:2179525

• Allelic Composition: Il2rb^tm1Mak/Il2rb^tm1Mak
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S2/SvPas)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:25940 )

• death occurs by 12 weeks of age

growth/size/body

weight loss ( J:25940 )

• mice start losing weight at three weeks of age

enlarged spleen ( J:25940 )

• is observed by three weeks of age

immune system

thymus hypoplasia ( J:25940 )

• about 10 fold less thymocytes compared to wild-type mice at six weeks of age

enlarged spleen ( J:25940 )

• is observed by three weeks of age

increased susceptibility to autoimmune hemolytic anemia ( J:25940 )

• mild anema occurs at 3 weeks of age

increased granulocyte number ( J:25940 )

• over 90% of cells in the spleen of 8 week old mice are composed of granulocytes and their precursors

increased neutrophil cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

abnormal mononuclear cell morphology ( J:25940 )

decreased double-positive T cell number ( J:25940 )

• about 3.5 fold less DP T cells at six weeks of age

increased plasma cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

decreased B cell number ( J:25940 )

• B cells are almost absent by 8 weeks of age

increased CD4-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD4 T cells in the thymus

increased CD8-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD8 T cells in the thymus

decreased memory T cell number ( J:25940 )

• memory T cells are not generated to LCMV virus

increased activated T cell number ( J:25940 )

• 4 fold increase in number of activated (CD69-positive) T cells from the mesenteric lymph nodes

abnormal B cell activation ( J:25940 )

• B cells are unable to respond to a T-cell independent antigen

increased IgE level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

increased IgG1 level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

abnormal T cell activation ( J:25940 )

• T cells fail to activate to a number of mitogens

enlarged lymph nodes ( J:25940 )

• is observed by three weeks of age

increased anti-nuclear antigen antibody level ( J:25940 )

• high concentrations occur in the sera by 3 weeks of age

endocrine/exocrine glands

thymus hypoplasia ( J:25940 )

• about 10 fold less thymocytes compared to wild-type mice at six weeks of age

abnormal sex gland morphology ( J:25940 )

• poorly developed genitalia are evident by six weeks of age

hematopoietic system

thymus hypoplasia ( J:25940 )

• about 10 fold less thymocytes compared to wild-type mice at six weeks of age

enlarged spleen ( J:25940 )

• is observed by three weeks of age

abnormal common myeloid progenitor cell morphology ( J:25940 )

• liver and spleen is infiltrated by large number of myeloid precursors

• around 8 weeks of age, bone marrow is also infiltrated

increased susceptibility to autoimmune hemolytic anemia ( J:25940 )

• mild anema occurs at 3 weeks of age

increased erythroid progenitor cell number ( J:25940 )

• increase numbers found in the blood between 3 and 8 weeks of age

increased granulocyte number ( J:25940 )

• over 90% of cells in the spleen of 8 week old mice are composed of granulocytes and their precursors

increased neutrophil cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

abnormal mononuclear cell morphology ( J:25940 )

decreased double-positive T cell number ( J:25940 )

• about 3.5 fold less DP T cells at six weeks of age

increased plasma cell number ( J:25940 )

• are found in lymph nodes starting about 4 weeks of age

decreased B cell number ( J:25940 )

• B cells are almost absent by 8 weeks of age

increased CD4-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD4 T cells in the thymus

increased CD8-positive, alpha-beta T cell number ( J:25940 )

• increase of single-positive CD8 T cells in the thymus

decreased memory T cell number ( J:25940 )

• memory T cells are not generated to LCMV virus

increased activated T cell number ( J:25940 )

• 4 fold increase in number of activated (CD69-positive) T cells from the mesenteric lymph nodes

abnormal B cell activation ( J:25940 )

• B cells are unable to respond to a T-cell independent antigen

increased IgE level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

increased IgG1 level ( J:25940 )

• 10 to 100 fold higher in the sera of 3 week old mice

abnormal T cell activation ( J:25940 )

• T cells fail to activate to a number of mitogens

behavior/neurological

abnormal locomotor behavior ( J:25940 )

• mice are slow when moving

reproductive system

abnormal sex gland morphology ( J:25940 )

• poorly developed genitalia are evident by six weeks of age

integument

abnormal hair texture ( J:25940 )

• hair is fuzzy in appearance