Phenotypes Associated with This Genotype

Genotype
MGI:2179294

• Allelic Composition: Rr158^tm1Cgn/Rr158^tm1Cgn
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:64287 , J:12574 )

• complete inhibition of immunoglobulin kappa chain V-J rearrangement (J:64287)

• light decrease in the number of splenic B cells which express only the lamda chain (expressed in about 5% of wild-type B cells); however spleen size is similar to wild-type (J:12574)

• complete inhibition of immunoglobulin kappa chain V-J rearrangement (J:12574)

decreased mature B cell number ( J:64287 )

• 2.3 fold less B cells in the spleen

• B cells expressing kappa chain completely absent in the spleen

• the percentage of newly generated B cell is half that of wild-type

increased mature B cell number ( J:64287 )

• 7 fold increase of lambda-chain expressing B cells in the bone marrow

spleen hypoplasia ( J:64287 )

• 30% fewer nucleated cells found in the spleen

hematopoietic system

abnormal B cell differentiation ( J:64287 , J:12574 )

• complete inhibition of immunoglobulin kappa chain V-J rearrangement (J:64287)

• light decrease in the number of splenic B cells which express only the lamda chain (expressed in about 5% of wild-type B cells); however spleen size is similar to wild-type (J:12574)

• complete inhibition of immunoglobulin kappa chain V-J rearrangement (J:12574)

decreased mature B cell number ( J:64287 )

• 2.3 fold less B cells in the spleen

• B cells expressing kappa chain completely absent in the spleen

• the percentage of newly generated B cell is half that of wild-type

increased mature B cell number ( J:64287 )

• 7 fold increase of lambda-chain expressing B cells in the bone marrow

spleen hypoplasia ( J:64287 )

• 30% fewer nucleated cells found in the spleen