Phenotypes Associated with This Genotype

Genotype
MGI:2179293

• Allelic Composition: Rr158^tm2Cgn/Rr158^tm2Cgn
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:12574 )

• 50% decrease in recombination of the Jk-kappa and V-kappa gene segments in splenic B cells

• B cells only express lambda chain (compared to 5% of wild-type B cells) B cells only express lambda chain (compared to 5% of wild-type B cells)

immune system

abnormal B cell differentiation ( J:12574 )

• 50% decrease in recombination of the Jk-kappa and V-kappa gene segments in splenic B cells

• B cells only express lambda chain (compared to 5% of wild-type B cells) B cells only express lambda chain (compared to 5% of wild-type B cells)