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Phenotypes Associated with This Genotype
Genotype
MGI:2179030
Allelic
Composition
Ptentm1Mak/Pten+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mak mutation (1 available); any Pten mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• 4% of mutants aged 26-29 weeks, 61% aged 30-49 weeks and 83% aged 50-65 weeks develop breast tumors, indicating an increased incidence of breast cancer as mice age
• small breast tumors are classified as fibroadenoma
• 49% of females develop breast tumors, most classified as Dunn's adenocarcinoma type C

neoplasm
• 14% develop spontaneous tumors during a 28 week observation period
• 4% of mutants aged 26-29 weeks, 61% aged 30-49 weeks and 83% aged 50-65 weeks develop breast tumors, indicating an increased incidence of breast cancer as mice age
• small breast tumors are classified as fibroadenoma
• 49% of females develop breast tumors, most classified as Dunn's adenocarcinoma type C
• 23% show marked expansion and proliferation of chromaffin cells of the adrenal medualla, consistent with medullary hyperplasia or pheochromocytoma; develop after 35 weeks of age
• 9% show hamartomatous lesions involving the mucosa of the stomach, duodenum, small bowel, colon, or anorectal junction
• 88% of the tumors are lymphoma/leukemia of the T-cell type
• older mice develop a range of lymphomas
• 18% develop malignant lymphomas
• 88% of the tumors are lymphoma/leukemia of the T-cell type
• 33% of tumors are teratocarcinoma
• 22% of females develop endometrial carcinoma, with the earliest case found at 30 weeks of age
• 19% of gamma-irradiated mutants develop tumors compared to none of wild-type
• tumors are thymic lymphomas/leukemias

digestive/alimentary system
• most mice exhibit microscopic hamartomatous polyps mainly in the colon

endocrine/exocrine glands
• 4% of mutants aged 26-29 weeks, 61% aged 30-49 weeks and 83% aged 50-65 weeks develop breast tumors, indicating an increased incidence of breast cancer as mice age
• small breast tumors are classified as fibroadenoma
• 49% of females develop breast tumors, most classified as Dunn's adenocarcinoma type C
• most mice exhibit focal atrophic changes in the seminiferous tubules
• 23% show marked expansion and proliferation of chromaffin cells of the adrenal medualla, consistent with medullary hyperplasia or pheochromocytoma; develop after 35 weeks of age
• 88% of the tumors are lymphoma/leukemia of the T-cell type

reproductive system
• most mice exhibit focal atrophic changes in the seminiferous tubules
• 22% of females develop endometrial carcinoma, with the earliest case found at 30 weeks of age
• all females 26 weeks of age or older show endometrial hyperplasia

immune system
• enlarged Peyer's patches composed of lymphohistiocytic infiltrates


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory