Phenotypes Associated with This Genotype

Genotype
MGI:2179029

• Allelic Composition: Pten^tm1Mak/Pten^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:50437 )

• die by E9.5

embryo

abnormal developmental patterning ( J:50437 )

• defective patterning of the cephalic and caudal regions

embryonic growth retardation ( J:50437 )

• embryos are developmentally delayed at E7.5

abnormal somite development ( J:50437 )

• fewer and less distinct somites

disorganized embryonic tissue ( J:50437 )

• E7.5 embryos are more compact and less organzied

abnormal allantois morphology ( J:50437 )

• display an expanded, loose and disorganized allantois

failure of chorioallantoic fusion ( J:50437 )

• fail to connect allantois and chorion

nervous system

abnormal brain development ( J:50437 )

• prominent and disproportionatea headfolds

growth/size/body

embryonic growth retardation ( J:50437 )

• embryos are developmentally delayed at E7.5