Phenotypes Associated with This Genotype

Genotype
MGI:2178224

• Allelic Composition: Minute/Minute⁺
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/6J * CBA/Ca * M. spretus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:75952 )

• while the expected number of mice inheriting the paternal allele are present at E18, by P1 only one third of expected mice are present

cellular

abnormal imprinting ( J:75952 )

• abnormal imprinting of Igf2 occurs with mice receiving the maternal allele having increased growth rates in utero while mice receiving the paternal allele having decreased in utero growth rates

embryo

decreased embryo weight ( J:75952 )

• at E13 mice carrying a paternally inherited allele are 83% of wild-type in weight

decreased placenta weight ( J:75952 )

• at E13 placental weight is 78% of wild-type and reaches 56% of wild-type at E18 in mice carrying a paternally inherited mutant allele

increased placenta weight ( J:75952 )

• with embryos inheriting a maternal allele

growth/size/body

decreased birth body size ( J:75952 )

• at birth mice carrying a paternally inherited allele are 55% of wild-type in size

decreased birth weight ( J:75952 )

• at birth, mice carrying a paternally inherited allele are 53% of wild-type weight

decreased body size ( J:75952 )

• in mice carrying a paternally inherited allele the size reduction observed at birth is maintained into adulthood

abnormal embryonic growth/weight/body size ( J:75952 )

• mice inheriting maternal allele measure 113% of wild-type and overgrowth reaches 108% of wild-type by P0

• mice inherting maternal allele have increased prenatal growth rates

decreased embryo weight ( J:75952 )

• at E13 mice carrying a paternally inherited allele are 83% of wild-type in weight