Phenotypes Associated with This Genotype

Genotype
MGI:2178060

• Allelic Composition: Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:36443 )

• some mice display bone fusions in the paws

decreased autopod size ( J:36443 )

• at birth, paw size is noticeably reduced

abnormal digit morphology ( J:153164 , J:36443 )

• toe 1 is malformed (J:153164)

• at birth, digit size is noticeably reduced (J:36443)

• secondary fusions between proximal digital elements results in Y-like digits or polysyndactyly (J:36443)

brachydactyly ( J:153164 , J:36443 )

• in all digits (J:153164)

• distal elements of digits are dramatically reduced in size (J:36443)

ectrodactyly ( J:71694 )

• both fore- and hindpaws have markedly shorter digits with absence of the second phalanges and an abnormal aspect of the digits, and the ectrodactyly in the hindpaw is less severe than in the hindpaw of Doxd13 homozyogtes

polydactyly ( J:71694 , J:153164 , J:36443 )

• observed in the hindpaw of most, if not all, homozygotes (J:71694)

• in the hind limbs (J:153164)

• conspicuous at birth (J:36443)

• additional digits are intercalated or fused, to either digit III or IV; invariably, animals have six defective and partially fused digits (J:36443)

polysyndactyly ( J:36443 )

abnormal digit development ( J:36443 )

• at E11 and E12, presumptive digit area is reduced in size

abnormal interdigital cell death ( J:36443 )

• at birth, webbing between vestigal digits is observed in all homozygotes

skeleton

delayed endochondral bone ossification ( J:36443 )

• cartilage remodeling in newborn animals is significantly delayed; characteristic columns of quiescent cells normally seen in controls are rarely apparent in mutants

cellular

abnormal interdigital cell death ( J:36443 )

• at birth, webbing between vestigal digits is observed in all homozygotes