Phenotypes Associated with This Genotype

Genotype
MGI:2177861

• Allelic Composition: Kmt2a^tm1Sjk/Kmt2a⁺
• Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:29958 )

♀

skeleton

abnormal sternum morphology ( J:29958 )

• 20 of 22 mice exhibit manubriosternebral abnormalities

• 17 of 22 mice exhibit xiphosternebral malformations

decreased rib number ( J:29958 )

• mice exhibit a complete loss or partial rib lose at T13

vertebral transformation ( J:29958 )

• mice exhibit C7/T13/L5 or C7/T12/L6 instead of C7/T13/L6 as in wild-type mice

thoracic vertebral transformation ( J:29958 )

• 18 of 22 mice exhibit T3 to T2 transformations

• 16 of 22 mice exhibit T2 to T1 transformations

• 8 of 22 mice exhibit T13 to L1 transformations

cervical vertebral transformation ( J:29958 )

• 14 of 22 mice exhibit C2 malformations compared to 4 of 29 mice

• 17 of 22 mice exhibit C7 to C6 transformations

lumbar vertebral transformation ( J:29958 )

• 19 of 22 mice exhibit L6 to S1 transformations

hematopoietic system

anemia ( J:29958 )

decreased erythrocyte cell number ( J:29958 )

decreased hemoglobin content ( J:29958 )

thrombocytopenia ( J:29958 )

decreased B cell number ( J:29958 )

growth/size/body

decreased birth body size ( J:29958 )

• mice are small at birth

postnatal growth retardation ( J:29958 )

immune system

decreased B cell number ( J:29958 )