Phenotypes Associated with This Genotype

Genotype
MGI:2177809

• Allelic Composition: Ptgs2^tm1Jed/Ptgs2^tm1Jed
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:29974 )

• homozygotes that reach weaning have an average lifespan of ~3.5 months, with a few animals surviving beyond 6 months

neonatal lethality, incomplete penetrance ( J:29974 )

• ~65% of homozygous mutant mice die neonatally

renal/urinary system

pyelonephritis ( J:29974 )

• all adult homozygotes with renal histopathology are susceptible to development of secondary pyelonephritis

abnormal kidney morphology ( J:29974 )

• all adult homozygotes exhibit renal dysplasia

abnormal kidney collecting duct morphology ( J:29974 )

• homozygous newborns show poor collecting duct development

abnormal kidney cortex morphology ( J:29974 )

abnormal renal glomerulus morphology ( J:29974 )

• all adult homozygotes exhibit mild to moderate renal lesions typified by numerous immature small glomeruli found subcapsularly

abnormal kidney corticomedullary boundary morphology ( J:29974 )

• homozygous newborns exhibit corticomedullary atrophy

kidney corticomedullary cyst ( J:29974 )

• all adult homozygotes display corticomedullary microcysts

abnormal kidney development ( J:29974 )

• although fetal metanephri appear normal at E14, kidneys of homozygous newborns appear severely underdeveloped relative to wild-type kidneys

abnormal kidney mesenchyme morphology ( J:29974 )

• homozygous newborns show abundant undifferentiated mesenchyme

kidney medulla hypoplasia ( J:29974 )

• all adult homozygotes display mild medullary hypoplasia or atrophy

abnormal renal tubule morphology ( J:29974 )

• all adult homozygotes exhibit mild to moderate renal lesions typified by multiple foci of dysplastic tubules

kidney failure ( J:29974 )

• adult homozygotes die of chronic renal failure of developmental origin

reproductive system

absent corpus luteum ( J:29974 )

♀ • mutant ovaries show virtual absence of corpora lutea, despite normal ovarian follicular development

small ovary ( J:29974 )

♀

decreased ovulation rate ( J:29974 )

♀

female infertility ( J:29974 )

♀ • homozygous females are largely infertile, rarely giving birth to live offspring

endocrine/exocrine glands

absent corpus luteum ( J:29974 )

♀ • mutant ovaries show virtual absence of corpora lutea, despite normal ovarian follicular development

small ovary ( J:29974 )

♀

cardiovascular system

cardiac fibrosis ( J:29974 )

• 50% of adult homozygotes exhibit diffuse myocardial fibrosis of variable severity involving both right and left ventricles

homeostasis/metabolism

increased circulating creatinine level ( J:29974 )

increased blood urea nitrogen level ( J:29974 )

immune system

immune system phenotype ( J:29974 )

N • homozygotes exhibit normal immune responses to carrageenan-induced paw edema, TPA-induced edema and arachidonic acid-induced edema

pyelonephritis ( J:29974 )

• all adult homozygotes with renal histopathology are susceptible to development of secondary pyelonephritis

hematopoietic system

hematopoietic system phenotype ( J:29974 )

N • homozygotes exhibit normal hematologic parameters

growth/size/body

kidney corticomedullary cyst ( J:29974 )

• all adult homozygotes display corticomedullary microcysts