Phenotypes Associated with This Genotype

Genotype
MGI:2177657

• Allelic Composition: Fus^{tm1(DDIT3)Dron}/Fus^{tm1(DDIT3)Dron}
• Genetic Background: involves: 129S6/SvEvTac * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:60224 )

endocrine/exocrine glands

small testis ( J:60224 )

♂ • progressive reduction in size resulting in adult testes two-thirds to half the size of those of wild-type

♂ • selective reduction in the volume of seminiferous epithelium

growth/size/body

decreased body size ( J:60224 )

• both males and females are ~70% the size of wild-type littermates at 3 weeks of age

decreased body weight ( J:60224 )

postnatal growth retardation ( J:60224 )

reproductive system

abnormal male meiosis ( J:60224 )

♂ • asynapsis observed 17.6% of pachytene nuclei

♂ • non-homologous synapsis observed in 3.9% of pachytene nuclei

♂ • increased apoptosis of pachytene spermatocytes

♂ • some progression through meiosis in spite of partial asynapsis

♂ • enlarged round spermatids

small testis ( J:60224 )

♂ • progressive reduction in size resulting in adult testes two-thirds to half the size of those of wild-type

♂ • selective reduction in the volume of seminiferous epithelium

reduced female fertility ( J:60224 )

♀ • litters produce by mutant females were approximately half the size of those birthed by wild-type females

decreased litter size ( J:60224 )

male infertility ( J:60224 )

♂ • males are infertile; however, serum testosterone levels are normal

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:60224 )

cellular

abnormal male meiosis ( J:60224 )

♂ • asynapsis observed 17.6% of pachytene nuclei

♂ • non-homologous synapsis observed in 3.9% of pachytene nuclei

♂ • increased apoptosis of pachytene spermatocytes

♂ • some progression through meiosis in spite of partial asynapsis

♂ • enlarged round spermatids