Phenotypes Associated with This Genotype

Genotype
MGI:2177642

• Allelic Composition: Tfam^tm1Lrsn/Tfam^tm1Lrsn; Tg(Camk2a-cre)1Lfr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:72037 )

• at 5-6 months of age, preceded by 1-2 weeks of rapid physical deterioration

nervous system

gliosis ( J:72037 )

• in corpus callosum, hippocampus; progressive with age

neurodegeneration ( J:72037 )

• degeneration of cortical organization in neocortex

neuron degeneration ( J:72037 )

• neuronal apoptosis in neocortex and hippocampus; progressive with age

axon degeneration ( J:72037 )

cellular

gliosis ( J:72037 )

• in corpus callosum, hippocampus; progressive with age

abnormal respiratory electron transport chain ( J:72037 )

• resipratory chain dysfunction in neurons of the neocortex and hippocampus