Phenotypes Associated with This Genotype

Genotype
MGI:2177575

• Allelic Composition: Gad2^tm1Bae/Gad2^tm1Bae
• Genetic Background: involves: 129X1/SvJ * NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:44638 )

behavior/neurological

seizures ( J:44638 )

• Background Sensitivity: exhibit an 11-fold higher incidence of stress-induced seizures than on the C57BL/6 background

• develop spontaneous seizures

nervous system

seizures ( J:44638 )

• Background Sensitivity: exhibit an 11-fold higher incidence of stress-induced seizures than on the C57BL/6 background

• develop spontaneous seizures

homeostasis/metabolism

decreased gamma-aminobutyric acid level ( J:44638 )

• Background Sensitivity: decrease in brain GABA levels unlike the normal levels on the C57BL/6 background, however glucose homeostasis is normal

reproductive system

reproductive system phenotype ( J:44638 )

N • normal fertility and development

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epilepsy		DOID:1826		J:44638
NOT	Stiff-Person syndrome	DOID:13366	OMIM:184850	J:44638