Phenotypes Associated with This Genotype

Genotype
MGI:2177572

• Allelic Composition: Gad1^tm1Oba/Gad1^tm1Oba
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gad1^tm1Oba/Gad1^tm1Oba mice and cleft palate

mortality/aging

neonatal lethality, complete penetrance ( J:40978 )

• homozygous mice are produced at Mendelian frequency and are initially indistinguishable from normal littermates, but die by P0.5

growth/size/body

cleft palate ( J:40978 )

distended abdomen ( J:40978 )

• after birth, mice display a gradual swelling of the bowels; stomach, jejunum and duodenum are filled with air

craniofacial

cleft palate ( J:40978 )

behavior/neurological

behavior/neurological phenotype ( J:40978 )

N • limb and trunk movements in newborns are coordinated without apparent neurological abnormalities

absent gastric milk in neonates ( J:40978 )

• stomachs of newborn homozygotes remain devoid of milk spots; however, suckling response is similar to that of wild-type mice

respiratory system

atelectasis ( J:40978 )

• lungs are partially aerated, but are mostly atelectatic

respiratory distress ( J:40978 )

• mice exhibit gasping after birth

homeostasis/metabolism

decreased gamma-aminobutyric acid level ( J:40978 )

• gamma isoaminobutryic acid (GABA) levels are 7% of wild-type levels in cerebral cortex at P0.5; similar degree of reduction is observed at E14.5

cyanosis ( J:40978 )

• newborns become cyanotic after birth

decreased glutamate decarboxylase activity ( J:40978 )

• glutamic acid decarboxylase activity is 20% of wild-type littermates at P0.5; similar degree of reduction is observed at E14.5

digestive/alimentary system

cleft palate ( J:40978 )