Phenotypes for Hexa MGI:2177433 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hexa^tm1Rlp/Hexa^tm1Rlp
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hexa^tm1Rlp mutation (1 available); any Hexa mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:21008 )

• accumulation of G_M2 gangliosides levels reach 15% of total gangliosides

• levels reach 15% of total gangliosides

abnormal neuron morphology ( J:21008 )

• number of storage neurons with membranous cytoplasmic bodies increases with age

• distribution of storage neurons found in cerebral cortex, piriform and entorhinal cortices, CA3, amygdala, mammillary bodies, septal nuclei, and nuclei in the hypothalamus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Tay-Sachs disease		DOID:3320	OMIM:272800	J:21008

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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