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Phenotypes Associated with This Genotype
Genotype
MGI:2177433
Allelic
Composition
Hexatm1Rlp/Hexatm1Rlp
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hexatm1Rlp mutation (1 available); any Hexa mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• accumulation of GM2 gangliosides levels reach 15% of total gangliosides (J:21008)
• levels reach 15% of total gangliosides (J:21008)
• accumulation of GM2 gangliosides levels reach 15% of total gangliosides (J:21008)
• levels reach 15% of total gangliosides (J:21008)
• number of storage neurons with membranous cytoplasmic bodies increases with age (J:21008)
• distribution of storage neurons found in cerebral cortex, piriform and entorhinal cortices, CA3, amygdala, mammillary bodies, septal nuclei, and nuclei in the hypothalamus (J:21008)
• number of storage neurons with membranous cytoplasmic bodies increases with age (J:21008)
• distribution of storage neurons found in cerebral cortex, piriform and entorhinal cortices, CA3, amygdala, mammillary bodies, septal nuclei, and nuclei in the hypothalamus (J:21008)

Mouse Models of Human Disease
OMIM ID Ref(s)
Tay-Sachs Disease; TSD 272800 J:21008


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory