Phenotypes Associated with This Genotype

Genotype
MGI:2177372

• Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:70409 )

• mutant animals die between P9 and P12

behavior/neurological

seizures ( J:70409 )

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:70409 )

• pancreatic beta cells are present, but have abnormal morphology

disorganized pancreatic islets ( J:70409 )

• disorganized morphology with non-beta cells present in the core

abnormal insulin secretion ( J:70409 )

• beta cells exhibit dysregulated insulin secretion

growth/size/body

postnatal growth retardation ( J:70409 )

• mutant animals are smaller than controls at P8

homeostasis/metabolism

abnormal insulin secretion ( J:70409 )

• beta cells exhibit dysregulated insulin secretion

hypoglycemia ( J:70409 )

• described as severe in mutant animals

decreased circulating glucagon level ( J:70409 )

• level was 5 fold less in mutant mice than in control animals

increased circulating insulin level ( J:70409 )

• the plasma insulin level was very high considering the low glucose levels in mutant animals

increased glycogen level ( J:70409 )

• mutant mice have a 2.5-fold higher glycogen content than controls

nervous system

seizures ( J:70409 )