Phenotypes for Tmc1 MGI:2177316 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tmc1^Mhdabth/Tmc1⁺
Genetic Background	C3HeB/FeJ-Tmc1^Mhdabth/Ieg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1^Mhdabth mutation (1 available); any Tmc1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:86685 )

• characterized as unsteady

hearing/vestibular/ear

deafness ( J:86685 )

• mice lose ability to hear with four to six weeks

• adult mice are completely deaf

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autosomal dominant nonsyndromic deafness 36	DOID:0110563	OMIM:606705	J:86685
autosomal recessive nonsyndromic deafness 7	DOID:0110520	OMIM:600974	J:86685

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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