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Phenotypes Associated with This Genotype
Genotype
MGI:2177237
Allelic
Composition
Brca2tm1Arge/Brca2tm2Arge
Waptm1(cre)Arge/Wap+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Arge mutation (0 available); any Brca2 mutation (60 available)
Brca2tm2Arge mutation (0 available); any Brca2 mutation (60 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

endocrine/exocrine glands
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

neoplasm
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:70564


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory