Mouse Genome Informatics
cn
    Brca2tm1Arge/Brca2tm2Arge
Waptm1(cre)Arge/Wap+

involves: 129S/SvEv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• mammary tumors occur after long latency of at least 13 months of age
• T50 for tumor-free survival is approximately 17 months of age
• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none
• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:70564