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Phenotypes Associated with This Genotype
Genotype
MGI:2177120
Allelic
Composition
Msr1tm1Csk/Msr1tm1Csk
Tg(APPV717F)109Ili/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation (2 available); any Msr1 mutation (4 available)
Tg(APPV717F)109Ili mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili
• loss of synaptophysin-immunoreactive presynaptic terminals in the hippocampal outer molecular layer (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili )
• reduced density of MAP-2 immuoreactive neuronal dendrites in the outer molecular layer of the hippocampus (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili)

homeostasis/metabolism
• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:58338


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory