Mouse Genome Informatics
involves: 129P2/OlaHsd * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
• heterozygotes exhibit abnormal hepatic glucose metabolism: hyperglycemia and hyperinsulinemia reduce hepatic glucose production by only 47% vs 72% in wild-type mice
• also, the fraction of hepatic UDPG pool derived from plasma glucose via the "direct" pathway is significantly reduced relative to wild-type
• at 5-6 months, heterozygous males show normoglycemia in the fed state
• however, heterozygotes show a mild (25%) increase in overnight fasting glucose levels relative to wild-type mice
• in contrast, plasma insulin levels remain unchanged relative to wild-type in both the fed and fasted state
• heterozygotes display reduced tolerance to glucose relative to wild-type mice

Mouse Models of Human Disease
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:28756