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Phenotypes Associated with This Genotype
Genotype
MGI:2176947
Allelic
Composition
Gcktm1Ts/Gcktm1Ts
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1Ts mutation (1 available); any Gck mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death between postnatal days 3 and 5 (P3 - P5)
• cessation of feeding postnatal day 3 (P3)

liver/biliary system
• microvesicular steatosis (vacuolization and lipid accumulation)

homeostasis/metabolism
• increased serum concentration of cholesterol
• increased serum concentrations of triglycerides
• reduction in glycogen stores

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maturity-onset diabetes of the young type 2 DOID:0111100 OMIM:125851
J:29255


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory