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Phenotypes Associated with This Genotype
Genotype
MGI:2176891
Allelic
Composition
Dmdmdx/Y
Dtnatm1Jrs/Dtnatm1Jrs
Utrntm1Jrs/Utrntm1Jrs
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (42 available); any Dmd mutation (159 available)
Dtnatm1Jrs mutation (1 available); any Dtna mutation (21 available)
Utrntm1Jrs mutation (2 available); any Utrn mutation (224 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 3 of 11 die before weaning
• lifespan is 3-11 weeks

growth/size/body
• exhibit poor growth

muscle
• develop a moderate to severe cardiomyopathy similar to that of double mutant Utrntm1Jrs and Dmdmdx mice
• develop severe skeletal dystrophy, however muscles are no more dystrophic than muscles of double Utrntm1Jrs and Dmdmdx mutant mice

cardiovascular system
• develop a moderate to severe cardiomyopathy similar to that of double mutant Utrntm1Jrs and Dmdmdx mice

skeleton

limbs/digits/tail
• severe limb contractures

nervous system
• distribution of acetylcholine receptors within synapse branches is abnormal, with a patchy or granular distribution

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:59675


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory