Mouse Genome Informatics
cx
    Dmdmdx/Y
Dtnatm1Jrs/Dtnatm1Jrs
Utrntm1Jrs/Utrntm1Jrs

involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 3 of 11 die before weaning (J:59675)
• lifespan is 3-11 weeks (J:59675)

growth/size/body
• exhibit poor growth (J:59675)

muscle
• develop a moderate to severe cardiomyopathy similar to that of double mutant Utrntm1Jrs and Dmdmdx mice (J:59675)
• develop severe skeletal dystrophy, however muscles are no more dystrophic than muscles of double Utrntm1Jrs and Dmdmdx mutant mice (J:59675)

cardiovascular system
• develop a moderate to severe cardiomyopathy similar to that of double mutant Utrntm1Jrs and Dmdmdx mice (J:59675)

skeleton
(J:59675)

limbs/digits/tail
• severe limb contractures (J:59675)

nervous system
• distribution of acetylcholine receptors within synapse branches is abnormal, with a patchy or granular distribution (J:60776)

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:59675