Phenotypes Associated with This Genotype

Genotype
MGI:2176875

• Allelic Composition: Utrn^tm1Ked/Utrn^tm1Ked
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:70949 )

• decrease in junctional folding at the postsynaptic membrane

• reduction in number of acetylcholine receptors in each junction

abnormal miniature endplate potential ( J:70949 )

• the amplitude of miniature endplate currents is reduced by 20% in the extensor digitorum longus muscle, however other features of neuromuscular transmission are normal

muscle

muscle phenotype ( J:70949 )

N • no indication of muscle weakness or degeneration of cardiac or skeletal muscle

renal/urinary system

renal/urinary system phenotype ( J:70949 )

N • normal kidney and function

respiratory system

respiratory system phenotype ( J:70949 )

N • no signs of abnormal breathing and the lung appears normal