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Phenotypes Associated with This Genotype
Genotype
MGI:2176850
Allelic
Composition
Gm2atm1Rlp/Gm2atm1Rlp
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gm2atm1Rlp mutation (1 available); any Gm2a mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• shorter latency to enter a dark chamber 24 hours after foot shock training relative to controls
• significantly impaired performance in a rotorod test
• no improvement in performance over time

nervous system
• Gm2 ganglioside accumulates in the brain at 4 months
• Ga2 ganglioside shows slight accumulations in the brain at 4 months
• pronounced ganglioside accumulations in the hypothalamic nuclei at 5 months
• pronounced ganglioside accumulations in the amygdala at 5 months
• pronounced ganglioside accumulations in the entorhinal cortex at 5 months
• ganglioside accumulations in large pyramidal neurons in the middle layer of the cerebral cortex at 5 months
• pronounced ganglioside accumulations in the piriform area at 5 months
• ganglioside storage at 5 months
• ganglioside storage in glial cells at 5 months
• ganglioside storage at 5 months
• ganglioside storage in glial cells at 5 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Gm2-Gangliosidosis, Ab Variant 272750 J:41950


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory