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Phenotypes Associated with This Genotype
Genotype
MGI:2176838
Allelic
Composition		 Gsk3btm1Jrw/Gsk3btm1Jrw
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1Jrw mutation (0 available); any Gsk3b mutation (111 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:63274 )
• between E13.5 and E14.5
• embryos could be rescued by i.p. injection of pregnant females at E10.5 or E11.5 with anti-TNF-alpha antibodies

liver/biliary system
abnormal liver morphology ( J:63274 )
• multifocal hemorrhagic degeneration
abnormal hepatocyte morphology ( J:63274 )
• apoptotic hepatocytes exhibiting pyknosis and karyorrhexis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory