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Phenotypes Associated with This Genotype
Genotype
MGI:2176786
Allelic
Composition
Brca1tm1Cxd/Brca1tm2Cxd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (75 available)
Brca1tm2Cxd mutation (1 available); any Brca1 mutation (75 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

endocrine/exocrine glands
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

neoplasm
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory