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Phenotypes Associated with This Genotype
Genotype
MGI:2176786
Allelic
Composition
Brca1tm1Cxd/Brca1tm2Cxd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (113 available)
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

endocrine/exocrine glands
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

integument
• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory