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Phenotypes Associated with This Genotype
Genotype
MGI:2176785
Allelic
Composition		 Brca1tm1Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (113 available)
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal mammary gland growth during pregnancy ( J:54533 )
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

neoplasm
increased mammary gland tumor incidence ( J:54533 )
• 3 of 10 female mice developed mammary tumors of diverse types

endocrine/exocrine glands
abnormal mammary gland development ( J:54533 )
• developmental defects may correlate with apoptosis observed in mutant mammary glands
abnormal branching of the mammary ductal tree ( J:54533 )
• abnormal ductal morphogenesis was observed at lactation and involution
abnormal involution of the mammary gland ( J:54533 )
• residual alveolar structures sometimes remain in involuting mammary glands
abnormal mammary gland growth during pregnancy ( J:54533 )
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants
increased mammary gland tumor incidence ( J:54533 )
• 3 of 10 female mice developed mammary tumors of diverse types

integument
abnormal mammary gland development ( J:54533 )
• developmental defects may correlate with apoptosis observed in mutant mammary glands
abnormal branching of the mammary ductal tree ( J:54533 )
• abnormal ductal morphogenesis was observed at lactation and involution
abnormal involution of the mammary gland ( J:54533 )
• residual alveolar structures sometimes remain in involuting mammary glands
abnormal mammary gland growth during pregnancy ( J:54533 )
• at pregnancy day 8.5, mammary glands are smaller than controls
• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants
increased mammary gland tumor incidence ( J:54533 )
• 3 of 10 female mice developed mammary tumors of diverse types

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory