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Phenotypes Associated with This Genotype
Genotype
MGI:2176767
Allelic
Composition
Nf1tm1Par/Nf1tm1Par
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Par mutation (4 available); any Nf1 mutation (85 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight and size are about 50% of normal
• 3-4 days after birth, mice begin to exhibit growth retardation that is sustained into adulthood

nervous system
• forebrain, but not the rest of the brain, is reduced in size, however mice exhibit normal neuronal development
• increase in cell density in the cerebral cortex, often resulting in less apparent lamination
• about 20% reduction in coritcal thickness
• mice display astrogliosis in various brain regions, however do not develop neuronal degeneration or microgliosis

behavior/neurological
• mice display severe learning disability

neoplasm
N
• no evidence of tumors; optic gliomas, astrocytomas, or neurofibroma are not observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:68558


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory