Mouse Genome Informatics
cn
    Nf1tm1Par/Nf1tm1Par
Tg(Syn1-cre)671Jxm/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
• body weight and size are about 50% of normal
• 3-4 days after birth, mice begin to exhibit growth retardation that is sustained into adulthood

nervous system
• forebrain, but not the rest of the brain, is reduced in size, however mice exhibit normal neuronal development
• increase in cell density in the cerebral cortex, often resulting in less apparent lamination
• about 20% reduction in coritcal thickness
• mice display astrogliosis in various brain regions, however do not develop neuronal degeneration or microgliosis

behavior/neurological
• mice display severe learning disability

tumorigenesis
N
• no evidence of tumors; optic gliomas, astrocytomas, or neurofibroma are not observed (J:68558)

Mouse Models of Human Disease
OMIM IDRef(s)
Neurofibromatosis, Type I; NF1 162200 J:68558