Phenotypes Associated with This Genotype

Genotype
MGI:2176599

• Allelic Composition: Adm^tm1Unc/Adm^tm1Unc
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Massive generalized edema of Adm^tm1Unc/Adm^tm1Unc embryos

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:67044 )

• embryos die between E13.5 and E14.5

cardiovascular system

abnormal artery morphology ( J:67044 )

• major arteries have thinner walls and are irregular in shape

abnormal myocardial trabeculae morphology ( J:67044 )

• left ventricular trabecular overdevelopment; increased number of trabeculae

disorganized myocardium ( J:67044 )

small heart ( J:67044 )

• mutant hearts are 2/3 of the normal size

abnormal heart left ventricle morphology ( J:67044 )

• the left ventricle has a thinner, convoluted compact zone

increased cardiomyocyte apoptosis ( J:106927 )

• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

embryo

increased placenta apoptosis ( J:201446 )

• increased apoptosis in the innermost border of the maternal-fetal interface of the placenta at E13.5

• increased apoptosis of parietal trophoblast cells

decreased uterine NK cell number ( J:201446 )

abnormal placenta labyrinth morphology ( J:201446 )

• in the innermost border of the maternal-fetal interface of the placenta at E13.5

• fetal vessels are abnormally large and under-branched compared to in wild-type mice

• increase in fetal space is accompanied by a decrease in maternal sinuses

• ovary transplantation experiments demonstrate that placental defects are independent of maternal genotype

• however, the total area of vascular space is normal

abnormal placenta fetal blood space morphology ( J:201446 )

• fetal sinuses of the placenta are larger than in wild-type mice

abnormal placenta intervillous maternal lacunae morphology ( J:201446 )

• decreased in maternal sinuses

abnormal visceral yolk sac morphology ( J:67044 )

• cavity distended

homeostasis/metabolism

hydrops fetalis ( J:67044 , J:106927 )

• general edema, associated with increased size of thoracic cavity (J:67044)

• onset of edema occurs at E13.5 (J:106927)

muscle

abnormal myocardial trabeculae morphology ( J:67044 )

• left ventricular trabecular overdevelopment; increased number of trabeculae

disorganized myocardium ( J:67044 )

increased cardiomyocyte apoptosis ( J:106927 )

• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

cellular

increased cardiomyocyte apoptosis ( J:106927 )

• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

increased placenta apoptosis ( J:201446 )

• increased apoptosis in the innermost border of the maternal-fetal interface of the placenta at E13.5

• increased apoptosis of parietal trophoblast cells

hematopoietic system

decreased uterine NK cell number ( J:201446 )

immune system

decreased uterine NK cell number ( J:201446 )

reproductive system

decreased uterine NK cell number ( J:201446 )

abnormal uterine spiral artery remodeling ( J:201446 )

• reduced maternal spiral artery remodeling with thick smooth muscle layer throughout the decidua

• reduced proliferation of endothelial cells in spiral arteries and failure to shed smooth muscle cells

endocrine/exocrine glands

decreased uterine NK cell number ( J:201446 )