Mouse Genome Informatics
hm
    Admtm1Unc/Admtm1Unc
involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Massive generalized edema of Admtm1Unc/Admtm1Unc embryos

mortality/aging
• embryos die between E13.5 and E14.5

cardiovascular system
• major arteries have thinner walls and are irregular in shape
• left ventricular trabecular overdevelopment; increased number of trabeculae
• mutant hearts are 2/3 of the normal size
• the left ventricle has a thinner, convoluted compact zone
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

embryogenesis
• in the innermost border of the maternal-fetal interface of the placenta at E13.5
• fetal vessels are abnormally large and under-branched compared to in wild-type mice
• increase in fetal space is accompanied by a decrease in maternal sinuses
• reduced maternal spiral artery remodeling with thick smooth muscle layer throughout the decidua
• ovary transplantation experiments demonstrate that placental defects are independent of maternal genotype
• however, the total area of vascular space is normal
• fetal sinuses of the placenta are larger than in wild-type mice
• reduced proliferation of endothelial cells in spiral arteries and failure to shed smooth muscle cells
• of parietal trophoblast cells

homeostasis/metabolism
• general edema, associated with increased size of thoracic cavity (J:67044)
• onset of edema occurs at E13.5 (J:106927)

muscle
• left ventricular trabecular overdevelopment; increased number of trabeculae
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

cellular
• in the innermost border of the maternal-fetal interface of the placenta at E13.5
• of parietal trophoblast cells
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum
• of parietal trophoblast cells

hematopoietic system

immune system

reproductive system

Mouse Models of Human Disease
OMIM IDRef(s)
Hydrops Fetalis, Nonimmune; NIHF 236750 J:67044