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Phenotypes Associated with This Genotype
Genotype
MGI:2176599
Allelic
Composition
Admtm1Unc/Admtm1Unc
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Unc mutation (0 available); any Adm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Massive generalized edema of Admtm1Unc/Admtm1Unc embryos

mortality/aging
• embryos die between E13.5 and E14.5 (J:67044)
• embryos die between E13.5 and E14.5 (J:67044)

cardiovascular system
• major arteries have thinner walls and are irregular in shape (J:67044)
• major arteries have thinner walls and are irregular in shape (J:67044)
• left ventricular trabecular overdevelopment; increased number of trabeculae (J:67044)
• left ventricular trabecular overdevelopment; increased number of trabeculae (J:67044)
• mutant hearts are 2/3 of the normal size (J:67044)
• mutant hearts are 2/3 of the normal size (J:67044)
• the left ventricle has a thinner, convoluted compact zone (J:67044)
• the left ventricle has a thinner, convoluted compact zone (J:67044)
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum (J:106927)
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum (J:106927)

embryogenesis
• of parietal trophoblast cells (J:201446)
• of parietal trophoblast cells (J:201446)
• in the innermost border of the maternal-fetal interface of the placenta at E13.5 (J:201446)
• fetal vessels are abnormally large and under-branched compared to in wild-type mice (J:201446)
• increase in fetal space is accompanied by a decrease in maternal sinuses (J:201446)
• ovary transplantation experiments demonstrate that placental defects are independent of maternal genotype (J:201446)
• however, the total area of vascular space is normal (J:201446)
• increase in fetal space is accompanied by a decrease in maternal sinuses (J:201446)
• in the innermost border of the maternal-fetal interface of the placenta at E13.5 (J:201446)
• fetal vessels are abnormally large and under-branched compared to in wild-type mice (J:201446)
• ovary transplantation experiments demonstrate that placental defects are independent of maternal genotype (J:201446)
• however, the total area of vascular space is normal (J:201446)
• fetal sinuses of the placenta are larger than in wild-type mice (J:201446)
• fetal sinuses of the placenta are larger than in wild-type mice (J:201446)
• decreased in maternal sinuses (J:201446)
• decreased in maternal sinuses (J:201446)
• cavity distended (J:67044)
• cavity distended (J:67044)

homeostasis/metabolism
• general edema, associated with increased size of thoracic cavity (J:67044)
• general edema, associated with increased size of thoracic cavity (J:67044)
• onset of edema occurs at E13.5 (J:106927)
• onset of edema occurs at E13.5 (J:106927)

muscle
• left ventricular trabecular overdevelopment; increased number of trabeculae (J:67044)
• left ventricular trabecular overdevelopment; increased number of trabeculae (J:67044)
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum (J:106927)
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum (J:106927)

cellular
• in the innermost border of the maternal-fetal interface of the placenta at E13.5 (J:201446)
• of parietal trophoblast cells (J:201446)
• in the innermost border of the maternal-fetal interface of the placenta at E13.5 (J:201446)
• of parietal trophoblast cells (J:201446)
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum (J:106927)
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum (J:106927)
• of parietal trophoblast cells (J:201446)
• of parietal trophoblast cells (J:201446)

hematopoietic system

immune system

reproductive system
• reduced maternal spiral artery remodeling with thick smooth muscle layer throughout the decidua (J:201446)
• reduced proliferation of endothelial cells in spiral arteries and failure to shed smooth muscle cells (J:201446)
• reduced maternal spiral artery remodeling with thick smooth muscle layer throughout the decidua (J:201446)
• reduced proliferation of endothelial cells in spiral arteries and failure to shed smooth muscle cells (J:201446)

endocrine/exocrine glands

Mouse Models of Human Disease
OMIM ID Ref(s)
Hydrops Fetalis, Nonimmune; NIHF 236750 J:67044


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory