Analysis Tools
behavior/neurological
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• mutants take less time to leave a perimeter outlined on a large table top over two test sessions
• on an elevated plus-maze, mutants spend more time in open arms and travel a greater distance than controls, indicating reduced anxiety
• mutants exhibit fewer closed arm SAPs and head dips, take less time to leave the center area to first enter an arm, and exhibit more head dips over the side of the open arms, all indicating reduced anxiety
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growth/size/body
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• females gain weight until 30 days of age, at which point they remain 10-15% smaller
• males gain weight similarly to wild type up until age 45, at which point they grow more slowly between 45 and 92 days of age, after which weight differences are not significant
• however, food intake is normal
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nervous system
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• calcium-stimulated adenylyl cyclase activity is almost entirely absent from the hypothalamus, olfactory bulb, thalamus, and brainstem and is reduced 40-50% in the hippocampus
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• no measurable LTD after low frequency stimulation in hippocampal slices derived from homozygous mice
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homeostasis/metabolism
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• mutants subjected to chronic restraint stress exhibit elevated basal corticosterone level before their final restraint compared with wild-type
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• calcium-stimulated adenylyl cyclase activity is almost entirely absent from the hypothalamus, olfactory bulb, thalamus, and brainstem and is reduced 40-50% in the hippocampus
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taste/olfaction
| N |
• normal odorant sensing
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