About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2176494
Allelic
Composition
Htttm1Mem/Htttm1Mem
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm1Mem mutation (1 available); any Htt mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by E8.5, all homozygous embryos are being resorbed, while only resorption sites are found at E9.5 (J:27183)
• by E8.5, all homozygous embryos are being resorbed, while only resorption sites are found at E9.5 (J:27183)

embryogenesis
• at E7.5, primitive streak at one end of embryos forms, but no node structure is evident (J:27183)
• at E7.5, primitive streak at one end of embryos forms, but no node structure is evident (J:27183)
• at E7.5, homozygous embryos are ~2/3 of normal size and misshapen; at E7.0, some homozygous embryos are observed to be smaller and thinner than other embryos in the litter (J:27183)
• at E7.5, homozygous embryos are ~2/3 of normal size and misshapen; at E7.0, some homozygous embryos are observed to be smaller and thinner than other embryos in the litter (J:27183)
• embryonic region appears shrunken at E7.5 (J:27183)
• embryonic region appears shrunken at E7.5 (J:27183)
• embryonic ectoderm is symmetrical and featureless, without evidence of head folds (J:27183)
• ectoderm is thicker than normal, and is disorganized rather than columnar especially distally (J:27183)
• embryonic ectoderm is symmetrical and featureless, without evidence of head folds (J:27183)
• ectoderm is thicker than normal, and is disorganized rather than columnar especially distally (J:27183)
• ~10% of cells are pyknotic compared to <1% in normal embryos (J:27183)
• ~10% of cells are pyknotic compared to <1% in normal embryos (J:27183)
• at E7.5, there is prominent constriction between the extraembryonic and embryonic regions of homozygotes (J:27183)
• at E7.5, there is prominent constriction between the extraembryonic and embryonic regions of homozygotes (J:27183)
• at E7.5, extraembryonic region is reduced in size (J:27183)
• at E7.5, extraembryonic region is reduced in size (J:27183)
• columnar cells of endoderm are not organized into tight sheath as in normal embryos, but form a folded layer extending around shrunken embryonic region (J:27183)
• columnar cells of endoderm are not organized into tight sheath as in normal embryos, but form a folded layer extending around shrunken embryonic region (J:27183)
• mesoderm cells line yolk sac, amnion, and chorion, but do not extend to distal pole (J:27183)
• cells are abnormally rounded and densely, not loosely, packed (J:27183)
• mesoderm cells line yolk sac, amnion, and chorion, but do not extend to distal pole (J:27183)
• cells are abnormally rounded and densely, not loosely, packed (J:27183)

growth/size/body
• at E7.5, homozygous embryos are ~2/3 of normal size and misshapen; at E7.0, some homozygous embryos are observed to be smaller and thinner than other embryos in the litter (J:27183)
• at E7.5, homozygous embryos are ~2/3 of normal size and misshapen; at E7.0, some homozygous embryos are observed to be smaller and thinner than other embryos in the litter (J:27183)

cellular
• ~10% of cells are pyknotic compared to <1% in normal embryos (J:27183)
• ~10% of cells are pyknotic compared to <1% in normal embryos (J:27183)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Huntington Disease; HD 143100 J:27183


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory