Phenotypes Associated with This Genotype

Genotype
MGI:2176442

• Allelic Composition: Ube2l3^m1Hrb/Ube2l3^m1Hrb
• Genetic Background: involves: 129/Sv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:36254 )

• none of the remaining 70% found alive at birth, assumed to die perinatally

lethality throughout fetal growth and development, incomplete penetrance ( J:36254 )

• 30% dead between E10.5 and term

embryo

embryonic growth retardation ( J:36254 )

• growth retardation in embryos surviving past E11.5

abnormal placenta morphology ( J:36254 )

abnormal placental labyrinth vasculature morphology ( J:36254 )

• increased branching and great variation in caliber of fetal blood vessels within placenta

abnormal placenta development ( J:36254 )

growth/size/body

embryonic growth retardation ( J:36254 )

• growth retardation in embryos surviving past E11.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:36254 )

• increased branching and great variation in caliber of fetal blood vessels within placenta