Phenotypes for Mif MGI:2176340 MGI Mouse

increased susceptibility to myocardial ischemic injury ( J:213776 )

• left ventricle contractile dysfunction and myocardial necrosis is more pronounced in isolated perfused hearts during reperfusion after ischemia than in wild-type hearts but less than in homozygous Cd74^tm1Eae hearts

increased myocardial infarct size ( J:213776 )

• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in wild-type hearts but is smaller than in homozygous Cd74^tm1Eae hearts

decreased circulating tumor necrosis factor level ( J:52300 )

• mutants stimulated with LPS or SEB show a 50% and 65%, respectively, reduction in the plasma levels of TNF-alpha compared to wild-type

• macrophages stimulated with LPS and interferon gamma show diminished production of TNF-alpha

increased interleukin-4 secretion ( J:52300 )

• lymph node cells from L. major infected mice show higher IL-4 production after antigen stimulation than cells from wild-type

decreased susceptibility to endotoxin shock ( J:52300 )

• mutants are resistant to the lethal effects of high dose bacterial lipopolysaccharide (LPS) and Staphylococcus aureus enterotoxin B (SEB) with D-galactosamine

• however, mutants are susceptible to a combination of low-dose LPS and D-galactosamine

decreased susceptibility to bacterial infection ( J:52300 )

• mutants clear gram-negative bacteria Pseudomonas aeruginosa instilled into the trachea better than wild-type and have diminished neutrophil accumulation in their bronchoalveolar fluid compared to wild-type

increased susceptibility to parasitic infection ( J:52300 )

• mice are more susceptible to the intracellular parasite L. major than wild-type