Phenotypes Associated with This Genotype

Genotype
MGI:2175910

• Allelic Composition: Apc^tm1Rfo/Apc^tm1Rfo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:55416 )

N • Background Sensitivity: unlike on a congenic C57BL/6J backround where mutants exhibit postnatal lethality, the expected numbers of homozygotes are observed on a mixed 129P2/OlaHsd and C57BL/6J background

endocrine/exocrine glands

absent male preputial gland ( J:55416 )

♂

growth/size/body

skin cyst ( J:55416 )

• always in proximity of the nipple, most males develop 1-3 cutaneous cysts ranging in size from 1-3 mm

• cysts are hybrid infundibular/matrical cysts lined by orthokeratinizing sqamous epithelium and stretches of matrix cells

decreased body size ( J:55416 )

• due to growth retardation

postnatal growth retardation ( J:55416 )

• 20% growth retardation is apparent by 10 days of age

reproductive system

absent male preputial gland ( J:55416 )

♂

renal/urinary system

absent male preputial gland ( J:55416 )

♂

neoplasm

neoplasm ( J:55416 )

N • mutants are tumor-free unlike most other Apc mutants

integument

absent male preputial gland ( J:55416 )

♂

skin cyst ( J:55416 )

• always in proximity of the nipple, most males develop 1-3 cutaneous cysts ranging in size from 1-3 mm

• cysts are hybrid infundibular/matrical cysts lined by orthokeratinizing sqamous epithelium and stretches of matrix cells