Phenotypes Associated with This Genotype

Genotype
MGI:2175861

• Allelic Composition: Erbb2^tm1Cbm/Erbb2^tm1Cbm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:48515 )

• die by E10.75

cardiovascular system

absent trabeculae carneae ( J:48515 )

nervous system

decreased Schwann cell precursor number ( J:48515 )

• numbers of early Schwann cell precursors that accompany projections of sensory and motor neurons are reduced at E10.5

abnormal sympathetic ganglion morphology ( J:48515 )

decreased neuronal precursor cell number ( J:48515 )

• severe reduction of neuronal precursors present in the primary sympathetic ganglion chain

• reduction of precursors of sympathetic neurons

abnormal cranial ganglia morphology ( J:48515 )

• abnormal appearance of cranial ganglia

muscle

absent trabeculae carneae ( J:48515 )

embryo

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions

cellular

decreased Schwann cell precursor number ( J:48515 )

• numbers of early Schwann cell precursors that accompany projections of sensory and motor neurons are reduced at E10.5

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions