Phenotypes Associated with This Genotype

Genotype
MGI:2175843

• Allelic Composition: Egfr^tm1Mag/Egfr^tm1Mag
• Genetic Background: involves: 129/Sv * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:26833 )

• Background Sensitivity: homozygotes exhibit perinatal lethality on a CD-1 background

embryonic lethality during organogenesis, complete penetrance ( J:26833 )

• on a 129/Sv-enriched genetic background, homozygotes die at midgestation with resorbing embryos evident at E12.5-E13.5

embryonic lethality at implantation, complete penetrance ( J:26833 )

• Background Sensitivity: homozygotes exhibit peri-implantation lethality on a CF1 background

embryo

decreased trophoblast giant cell number ( J:26833 )

• at E12.5-E13.5, the labyrinthine trophoblast cell number is reduced

decreased spongiotrophoblast size ( J:26833 )

• at E12.5-E13.5, the mutant spongiotrophoblast is significantly reduced

abnormal placenta labyrinth morphology ( J:26833 )

• at E12.5-E13.5, the labyrinthine trophoblast appears disorganized and hypoplastic

• in contrast, the organization and cell number of the trophoblast giant-cell layer is unremarkable

small placenta ( J:26833 )

• at E12.5-E13.5, mutant placentas are smaller than wild-type