Phenotypes Associated with This Genotype

Genotype
MGI:2175842

• Allelic Composition: Egfr^tm1Mag/Egfr^tm1Mag
• Genetic Background: involves: 129S2/SvPas * CF-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:26833 )

• on a CF1-enriched genetic background, homozygotes die before E7.5; only 2% of homozygotes are obtained at E6.5

embryo

abnormal inner cell mass morphology ( J:26833 )

• at E4.5-E4.8, 6 of 32 homozygotes exhibit small, loosely arranged inner cell masses with no distinct endoderm

• at E5.1-E5.5, 13 of 61 mutant embryos are collapsed; by E6.5, 8 of 31 decidua lack an embryo and are filled with maternal blood