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Phenotypes Associated with This Genotype
Genotype
MGI:2175826
Allelic
Composition
Dbhtm1Rpa/Dbhtm1Rpa
Genetic
Background
either: (involves: 129S7/SvEvBrd * 129/SvCpj) or (involves: 129S7/SvEvBrd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbhtm1Rpa mutation (2 available); any Dbh mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• of those that survive to term, 40% die within 48 hours of birth
• of those that survive to term, 20% die between 3-5 weeks of age
• onset E11.5, incompletely penetrant, some survive to birth and later; phenotype rescued when mothers treated with DOPS

growth/size/body
• runting apparent by P7
• by P21, weight about 50% of controls and eventually grow to 80% and 88% of male and female adult weight, respectively
• growth phase that occurs normally between 3 and 5 weeks is delayed by one to two weeks

vision/eye

cardiovascular system
• greater heterogeneity in cell size and cellular orientation in E12.5-E15.5 embryos

nervous system
• in E11.5 embryos

homeostasis/metabolism
• in E11.5 embryos
• in E11.5 embryos
• in E11.5 embryos

Mouse Models of Human Disease
OMIM ID Ref(s)
Dopamine Beta-Hydroxylase Deficiency, Congenital 223360 J:24414


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory