Mouse Genome Informatics
hm
    Dbhtm1Rpa/Dbhtm1Rpa
either: (involves: 129S7/SvEvBrd * 129/SvCpj) or (involves: 129S7/SvEvBrd * C57BL/6J)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• of those that survive to term, 40% die within 48 hours of birth
• of those that survive to term, 20% die between 3-5 weeks of age
• onset E11.5, incompletely penetrant, some survive to birth and later; phenotype rescued when mothers treated with DOPS

growth/size
• runting apparent by P7
• by P21, weight about 50% of controls and eventually grow to 80% and 88% of male and female adult weight, respectively
• growth phase that occurs normally between 3 and 5 weeks is delayed by one to two weeks

vision/eye

cardiovascular system
• greater heterogeneity in cell size and cellular orientation in E12.5-E15.5 embryos

nervous system
• in E11.5 embryos

homeostasis/metabolism
• in E11.5 embryos
• in E11.5 embryos
• in E11.5 embryos

Mouse Models of Human Disease
OMIM IDRef(s)
Dopamine Beta-Hydroxylase Deficiency, Congenital 223360 J:24414