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Phenotypes Associated with This Genotype
Genotype
MGI:2175792
Allelic
Composition
CrebbpGt(U-San)112Imeg/Crebbp+
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrebbpGt(U-San)112Imeg mutation (0 available); any Crebbp mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a subset of F2 heterozygous pups die within several days after birth (J:53370)
• a subset of F2 heterozygous pups die within several days after birth (J:53370)

growth/size/body
• at death, heterozygotes fed a high-carbohydrate (HC) diet display a significantly reduced fat mass relative to similarly fed wild-type mice (J:75361)
• however, at P3, heterozygotes contain the same amount of BAT and WAT as wild-type mice (J:75361)
• at death, heterozygotes fed a high-carbohydrate (HC) diet display a significantly reduced fat mass relative to similarly fed wild-type mice (J:75361)
• however, at P3, heterozygotes contain the same amount of BAT and WAT as wild-type mice (J:75361)
• at 2-14 weeks, heterozygotes show a 30% reduction in body weight relative to wild-type mice (J:75361)
• however, heterozygotes gain weight at a rate that is comparable to that observed in wild-type mice (J:75361)
• at 2-14 weeks, heterozygotes show a 30% reduction in body weight relative to wild-type mice (J:75361)
• however, heterozygotes gain weight at a rate that is comparable to that observed in wild-type mice (J:75361)
• in contrast to wild-type mice, heterozygotes fail to show a time-dependent increase in weight on a high-fat (HF) diet (J:75361)
• heterozygotes appear to be protected against HF diet-induced triglyceride accumulation in WAT (J:75361)
• in contrast to wild-type mice, heterozygotes fail to show a time-dependent increase in weight on a high-fat (HF) diet (J:75361)
• heterozygotes appear to be protected against HF diet-induced triglyceride accumulation in WAT (J:75361)
• heterozygotes exhibit significant intrauterine growth retardation in both weight and height relative to wild-type embryos (J:53370)
• heterozygotes exhibit significant intrauterine growth retardation in both weight and height relative to wild-type embryos (J:53370)

craniofacial
• at 19 dpc, heterozygotes exhibit a large anterior fontanel (J:53370)
• at 19 dpc, heterozygotes exhibit a large anterior fontanel (J:53370)
• heterozygotes display widening of the frontal bone (J:53370)
• heterozygotes display widening of the frontal bone (J:53370)

skeleton
• at 19 dpc, heterozygotes exhibit a large anterior fontanel (J:53370)
• at 19 dpc, heterozygotes exhibit a large anterior fontanel (J:53370)
• heterozygotes display widening of the frontal bone (J:53370)
• heterozygotes display widening of the frontal bone (J:53370)
• 1 of 30 heterozygotes display severe scoliosis (J:53370)
• 1 of 30 heterozygotes display severe scoliosis (J:53370)
• heterozygotes exhibit delayed osseous maturation; notably, neither broad thumbs nor broad halluces are observed (J:53370)
• heterozygotes exhibit delayed osseous maturation; notably, neither broad thumbs nor broad halluces are observed (J:53370)

cardiovascular system
• at 19.5 dpc, 9 of 54 heterozygous fetuses (16.6%) display non-overlapping cardiac abnormalities (J:53370)
• at 19.5 dpc, 9 of 54 heterozygous fetuses (16.6%) display non-overlapping cardiac abnormalities (J:53370)
• at 19.5 dpc, 1 of 54 heterozygous fetuses exhibit a bicuspid valve (J:53370)
• at 19.5 dpc, 1 of 54 heterozygous fetuses exhibit a bicuspid valve (J:53370)
• at 19.5 dpc, 1 of 54 heterozygous fetuses exhibit an atrial septal defect (J:53370)
• at 19.5 dpc, 1 of 54 heterozygous fetuses exhibit an atrial septal defect (J:53370)
• at 19.5 dpc, 7 of 54 heterozygous fetuses exhibit a ventricular septal defect of the membranous type (J:53370)
• at 19.5 dpc, 7 of 54 heterozygous fetuses exhibit a ventricular septal defect of the membranous type (J:53370)

behavior/neurological
• heterozygotes display impaired long-term memory (LTM) in a step-through-type passive avoidance test and a cued fear-conditioning test (J:53370)
• in contrast, heterozygotes exhibit normal short-term memory in a Y-maze test as well as normal spatial learning in a water maze test (J:53370)
• heterozygotes display impaired long-term memory (LTM) in a step-through-type passive avoidance test and a cued fear-conditioning test (J:53370)
• in contrast, heterozygotes exhibit normal short-term memory in a Y-maze test as well as normal spatial learning in a water maze test (J:53370)
• hypolocomotion in a dark environment is noted throughout the entire 60 min observation period in the vertical activity, but only in the first 5 min in the horizontal activity (J:53370)
• hypolocomotion in a dark environment is noted throughout the entire 60 min observation period in the vertical activity, but only in the first 5 min in the horizontal activity (J:53370)
• heterozygotes display hypolocomotion in a dark environment but not in a light environment (J:53370)
• heterozygotes display hypolocomotion in a dark environment but not in a light environment (J:53370)
• at least 2 of 54 heterozygotes display seizures (J:53370)
• at least 2 of 54 heterozygotes display seizures (J:53370)

nervous system
N
• heterozygotes exhibit a normal brain morphology: despite the LTM deficit, neither sensorimotor nor gross neuroanatomical anomalies are observed (J:53370)
• heterozygotes exhibit a normal brain morphology: despite the LTM deficit, neither sensorimotor nor gross neuroanatomical anomalies are observed (J:53370)
• at least 2 of 54 heterozygotes display seizures (J:53370)
• at least 2 of 54 heterozygotes display seizures (J:53370)

limbs/digits/tail
• 1 of 30 heterozygotes exhibit oligodactyly (J:53370)
• 1 of 30 heterozygotes exhibit oligodactyly (J:53370)

adipose tissue
• at death, heterozygotes fed a high-carbohydrate (HC) diet display a significantly reduced fat mass relative to similarly fed wild-type mice (J:75361)
• however, at P3, heterozygotes contain the same amount of BAT and WAT as wild-type mice (J:75361)
• at death, heterozygotes fed a high-carbohydrate (HC) diet display a significantly reduced fat mass relative to similarly fed wild-type mice (J:75361)
• however, at P3, heterozygotes contain the same amount of BAT and WAT as wild-type mice (J:75361)
• at 8 months, heterozygotes show a significant reduction in WAT weight per body weight; the weight of other tissues, including brown adipose tissue, remains unchanged (J:75361)
• reduced WAT mass is attributed to the inhibition of triglyceride accumulation in WAT (J:75361)
• at 8 months, heterozygotes show a significant reduction in WAT weight per body weight; the weight of other tissues, including brown adipose tissue, remains unchanged (J:75361)
• reduced WAT mass is attributed to the inhibition of triglyceride accumulation in WAT (J:75361)
• at 8 months, heterozygotes fed a HC diet show a marked reduction in adipocyte size relative to similarly fed wild-type mice (J:75361)
• at 8 months, heterozygotes fed a HC diet show a marked reduction in adipocyte size relative to similarly fed wild-type mice (J:75361)

cellular
in vitro, embryonic fibroblasts from heterozygous mice exhibit a reduced ability to differentiate into adipocytes upon induction with conventional hormonal stimuli (J:75361)
in vitro, embryonic fibroblasts from heterozygous mice exhibit a reduced ability to differentiate into adipocytes upon induction with conventional hormonal stimuli (J:75361)

homeostasis/metabolism
• in contrast to wild-type mice, heterozygotes fail to show a time-dependent increase in weight on a high-fat (HF) diet (J:75361)
• heterozygotes appear to be protected against HF diet-induced triglyceride accumulation in WAT (J:75361)
• in contrast to wild-type mice, heterozygotes fail to show a time-dependent increase in weight on a high-fat (HF) diet (J:75361)
• heterozygotes appear to be protected against HF diet-induced triglyceride accumulation in WAT (J:75361)
• heterozygotes show higher plasma insulin levels during glucose tolerance tests suggesting increased insulin secretion; however, this rise in insulin levels does not reach statistical significance (J:75361)
• heterozygotes show higher plasma insulin levels during glucose tolerance tests suggesting increased insulin secretion; however, this rise in insulin levels does not reach statistical significance (J:75361)
• heterozygotes fed a HF diet display increased serum leptin levels relative to the severely reduced WAT mass (J:75361)
• in addition, heterozygotes fed a HF diet exhibit increased leptin sensitivity in response to exogenous leptin (J:75361)
• heterozygotes fed a HF diet display increased serum leptin levels relative to the severely reduced WAT mass (J:75361)
• in addition, heterozygotes fed a HF diet exhibit increased leptin sensitivity in response to exogenous leptin (J:75361)
• heterozygotes fed a HF diet display reduced serum levels of free fatty acids relative to wild-type mice (J:75361)
• heterozygotes fed a HF diet display reduced serum levels of free fatty acids relative to wild-type mice (J:75361)
• heterozygotes exhibit a marked increase in resting oxygen consumption relative to wild-type mice (J:75361)
• in contrast, food intake remains relatively unchanged on either the HC or HF diet (J:75361)
• heterozygotes exhibit a marked increase in resting oxygen consumption relative to wild-type mice (J:75361)
• in contrast, food intake remains relatively unchanged on either the HC or HF diet (J:75361)
• heterozygotes display increased glucose tolerance relative to wild-type mice on both a HC and a HF diet (J:75361)
• heterozygotes display increased glucose tolerance relative to wild-type mice on both a HC and a HF diet (J:75361)
• despite lipodystrophy, heterozygotes exhibit an enhanced glucose-lowering insulin effect relative to wild-type mice (J:75361)
• despite lipodystrophy, heterozygotes exhibit an enhanced glucose-lowering insulin effect relative to wild-type mice (J:75361)
• heterozygotes fed a HF diet show a significant increase in serum adiponectin levels, despite their markedly reduced WAT mass (J:75361)
• heterozygotes fed a HF diet show a significant increase in serum adiponectin levels, despite their markedly reduced WAT mass (J:75361)
• heterozygotes display changes in gene expression associated with decreased tissue triglyceride content in skeletal muscle and liver (J:75361)
• heterozygotes display changes in gene expression associated with decreased tissue triglyceride content in skeletal muscle and liver (J:75361)
• heterozygotes fed a HF diet display reduced Tnfa mRNA levels in WAT relative to wild-type mice (J:75361)
• heterozygotes fed a HF diet display reduced Tnfa mRNA levels in WAT relative to wild-type mice (J:75361)

immune system
• heterozygotes fed a HF diet display reduced Tnfa mRNA levels in WAT relative to wild-type mice (J:75361)
• heterozygotes fed a HF diet display reduced Tnfa mRNA levels in WAT relative to wild-type mice (J:75361)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rubinstein-Taybi Syndrome 1; RSTS1 180849 J:53370


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory