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Phenotypes Associated with This Genotype
Genotype
MGI:2175790
Allelic
Composition
Cr2tm1Hmo/Cr2tm1Hmo
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Hmo mutation (1 available); any Cr2 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• although serum levels of IgG in general are normal in unimmunized mice, a significantly reducted response of IgG1 occurs after immunization with T-cell dependent antigen
• a significantly reducted response of IgG2a, IgG2b and IgG3 occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
• although serum levels are normal in unimmunized mice, a significant reduction in response occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls

hematopoietic system
• although serum levels of IgG in general are normal in unimmunized mice, a significantly reducted response of IgG1 occurs after immunization with T-cell dependent antigen
• a significantly reducted response of IgG2a, IgG2b and IgG3 occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
• although serum levels are normal in unimmunized mice, a significant reduction in response occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory