Analysis Tools
endocrine/exocrine glands
neoplasm
|
• by 2 months of age,tumors began to develop and by 6 months 6 of 18 mice had malignant tumors
|
|
• following DMBA treatment 1 week after birth, 9 of 11 mice developed skin tumors by 9-20 weeks of age with 2 mice developing invasive epidermoid carcinomas and 3 mice developing 2 tumors of different histological types
• DMBA induced tumors skin tumors occurred at multiple sites and had varying degrees of anaplasia
|
|
• malignant fibrous histocytoma
|
|
• when p185BCR-ABL positive pro/pre-B cells from cultured bone marrow progenitors from mice with this genotype were injected into wild-type mice
|
|
• in the brain
|
|
• metastatic salivary gland carcinoma
|
|
• 2 of 18 had fibrosarcomas
|
|
• following gamma-irradiation of newborn mice, 4 of 6 mice developed fibrosarcomas or anaplastic T cell lymphomas
|
reproductive system
 |
• with increasing age
|
|
|
• p53-dependent apoptosis during pachytene
|
cellular
|
|
• with increasing age
|
|
|
• p53-dependent apoptosis during pachytene
|
|
• MEFs were less responsive to contact-induced growth inhibition
|
|
• MEFs showed increased proliferative capacity, faster growth rate, and no senescence crisis was ever detected
|
vision/eye
| N |
• despite expression in the cornea, no obvious thinning of the cornea is detected
|
|
• at around P14, the lens undergoes degenerative changes characterized by vacuolization and lens material degradation; an attempt at lens repair beyond P14 is manifested by the accumulation of lens epithelial cells lining a regenerated posterior capsule
• attachment of the retrolental tissue to the posterior lens and extrusion of lens material into the retrolental tissue
|
|
• lens capsule destruction
|
|
• failure of hyaloid vascular regression that causes a pathological process that resembles persistent hyperplastic primary vitreous
(J:75215)
• proliferation continues in the hyperplastic primary vitreous at E18.5
(J:149526)
|
|
• show increased cell proliferation in the developing vitreous between E12.5 and E13.5
|
|
• at P14 and beyond, the neuroretina is abnormal, with the presence of retinal folds, progressive physical attachment of the retrolental mass to the neuroretina, and progressive detachment of the neuroretina from the retina pigment epithelium
|
|
• at P14 and beyond, the retina exhibits rosette-like arrangements of dysplastic photoreceptor cells
|
|
• in the areas where observe progressive physical attachment of the retrolental mass to the neuroretina, the ganglion cell layer is disorganized
|
|
• in the areas where observe progressive physical attachment of the retrolental mass to the neuroretina, the inner nuclear cell layer is disorganized
|
|
• at P14 and beyond, exhibit progressive detachment of the neuroretina from the retina pigment epithelium
(J:75215)
• caused by aberrant accumulation of mural pericytes and development of a retrolental mass in early postnatal period
(J:244260)
|
retina fold
(
J:75215
)
|
• presence of retinal folds at P14 and beyond
|
|
• retina detaches and collapses into lens in early postnatal period
|
nervous system
|
• at P14 and beyond, the retina exhibits rosette-like arrangements of dysplastic photoreceptor cells
|
homeostasis/metabolism
|
• following DMBA treatment 1 week after birth, 9 of 11 mice developed skin tumors by 9-20 weeks of age with 2 mice developing invasive epidermoid carcinomas and 3 mice developing 2 tumors of different histological types
• DMBA induced tumors skin tumors occurred at multiple sites and had varying degrees of anaplasia
|
integument
|
• malignant fibrous histocytoma
|
