Analysis Tools
mortality/aging
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• Background Sensitivity: no indication of early mortality at 9 months of age on the mixed 129/Sv and C57BL/6J background, however on a 129/Sv background, majority die with massively enlarged pituitary tumors
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growth/size/body
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• body weight increase becomes evident between 2-3 weeks of age, is maximal by 10 weeks of age, and is maintained throughout adulthood and is partly attributable to enlargement of all internal organs, however do not have an increase in body fat amount
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• disproportionately enlarged
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• becomes evident by 4 weeks of age
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neoplasm
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• adenomatous, neoplastic transformation of the pars intermedia
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endocrine/exocrine glands
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• disproportionately enlarged
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• gross hyperplasia becomes evident at 8-10 weeks of age
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• disproportionately enlarged
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• becomes evident by 4 weeks of age
• 3-fold increase in the number of thymocytes, however development of thymocytes is normal
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• secondary ovarian follicles develop but do not progress to form corpora lutea
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• adenomatous, neoplastic transformation of the pars intermedia
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immune system
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• thymoblasts and splenic T cells have an increase in percentage of S phase cells and a 3-4-fold increase in cyclin E-associated kinase activity, indicating increased cell proliferation
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• disproportionately enlarged
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• becomes evident by 4 weeks of age
• 3-fold increase in the number of thymocytes, however development of thymocytes is normal
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• disproportionately enlarged
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• becomes evident by 4 weeks of age
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hematopoietic system
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• thymoblasts and splenic T cells have an increase in percentage of S phase cells and a 3-4-fold increase in cyclin E-associated kinase activity, indicating increased cell proliferation
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• disproportionately enlarged
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• becomes evident by 4 weeks of age
• 3-fold increase in the number of thymocytes, however development of thymocytes is normal
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• increase in the number of granulocyte-macrophage, early and late erythroid progenitors, and megakaryotic progenitors in both the marrow and spleen
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• disproportionately enlarged
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• becomes evident by 4 weeks of age
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liver/biliary system
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• average of 23% increase in hepatocyte cell density
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reproductive system
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• secondary ovarian follicles develop but do not progress to form corpora lutea
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• females do not become pregnant, however, exogenous administration of gonadotropins induced ovulation, differentiation of the corpora lutea, and early development of viable embryos, with embryos implanting but not developing to term
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vision/eye
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• loss of the normally sharp boundary between the inner and outer nuclear layer
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• subtle disorganization of the retina
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nervous system
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• disproportionately enlarged
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• gross hyperplasia becomes evident at 8-10 weeks of age
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• adenomatous, neoplastic transformation of the pars intermedia
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• about 30% increase in neuronal cell density in the habenular nucleus
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• about 30% increase in neuronal cell density in the hippocampus
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• about 30% increase in neuronal cell density in the cerebral cortex
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cellular
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• thymoblasts and splenic T cells have an increase in percentage of S phase cells and a 3-4-fold increase in cyclin E-associated kinase activity, indicating increased cell proliferation
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