Phenotypes Associated with This Genotype

Genotype
MGI:2175759

• Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:33401 )

• weigh 20-40% more than littermate controls

increased spleen weight ( J:33401 )

• weight of spleen is increased relative to the increase in body size

endocrine/exocrine glands

abnormal pituitary intermediate lobe morphology ( J:50053 )

• at 30 weeks of age, a marked increase in vascularity is seen in the intermediate lobe, manifested as lakes of distended capillaries filled with red blood cells

pituitary intermediate lobe hyperplasia ( J:33401 , J:50053 )

increased thymus weight ( J:33401 )

• weight of thymus is increased relative to the increase in body size

increased thymocyte number ( J:33401 )

• detect an increase in the number of splenic T cells and an increase in the number of proliferating thymocytes in the thymus, in both the cortical and medullary regions

abnormal corpus luteum morphology ( J:33401 )

♀ • ovaries show defective formation of the corpus luteum

increased pituitary gland tumor incidence ( J:50053 )

• older mice (8 and 11 months of age) develop pituitary tumors, however none die of the tumors

immune system

increased thymus weight ( J:33401 )

• weight of thymus is increased relative to the increase in body size

increased thymocyte number ( J:33401 )

• detect an increase in the number of splenic T cells and an increase in the number of proliferating thymocytes in the thymus, in both the cortical and medullary regions

increased spleen weight ( J:33401 )

• weight of spleen is increased relative to the increase in body size

reproductive system

abnormal corpus luteum morphology ( J:33401 )

♀ • ovaries show defective formation of the corpus luteum

prolonged estrus ( J:33401 )

♀ • females typically show a prolongation prior to oestrous and a delay in exiting oestrous

prolonged estrous cycle ( J:33401 )

♀ • females exhibit prolonged oestrous cycles

female infertility ( J:33401 )

♀ • although ovulation and fertilization occur, females do not maintain pregnancies

hematopoietic system

increased thymus weight ( J:33401 )

• weight of thymus is increased relative to the increase in body size

increased thymocyte number ( J:33401 )

• detect an increase in the number of splenic T cells and an increase in the number of proliferating thymocytes in the thymus, in both the cortical and medullary regions

increased spleen weight ( J:33401 )

• weight of spleen is increased relative to the increase in body size

nervous system

abnormal pituitary intermediate lobe morphology ( J:50053 )

• at 30 weeks of age, a marked increase in vascularity is seen in the intermediate lobe, manifested as lakes of distended capillaries filled with red blood cells

pituitary intermediate lobe hyperplasia ( J:33401 , J:50053 )

increased pituitary gland tumor incidence ( J:50053 )

• older mice (8 and 11 months of age) develop pituitary tumors, however none die of the tumors

neoplasm

increased pituitary gland tumor incidence ( J:50053 )

• older mice (8 and 11 months of age) develop pituitary tumors, however none die of the tumors