Phenotypes Associated with This Genotype

Genotype
MGI:2175212

• Allelic Composition: Agtpbp1^{pcd-Tg(Dhfr)1Jwg}/Agtpbp1^{pcd-Tg(Dhfr)1Jwg}
• Genetic Background: involves: C57BL/6J * CD-1 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:9814 , J:14991 )

• age of onset 3 weeks (J:9814)

• developed at ~ 3 weeks (J:14991)

reproductive system

azoospermia ( J:9814 )

♂ • in sterile males

decreased litter size ( J:9814 )

• females fertile, but produced small litters

male infertility ( J:9814 , J:14991 )

♂ • incomplete penetrance, ~1/3 of males were sterile (J:9814)

♂ • incomplete penetrance (J:14991)

vision/eye

retina photoreceptor degeneration ( J:9814 , J:14991 )

• photoreceptor cell degeneration slower than Purkinje cell degeneration (J:9814)

• slower degeneration than Purkinje cells (J:14991)

nervous system

abnormal olfactory bulb morphology ( J:9814 , J:14991 )

• mitral cells of olfactory bulb degenerate more slowly than Purkinje cells (J:9814)

Purkinje cell degeneration ( J:9814 , J:14991 )

• rapid degeneration (J:14991)

retina photoreceptor degeneration ( J:9814 , J:14991 )

• photoreceptor cell degeneration slower than Purkinje cell degeneration (J:9814)

• slower degeneration than Purkinje cells (J:14991)

cellular

azoospermia ( J:9814 )

♂ • in sterile males