Phenotypes Associated with This Genotype

Genotype
MGI:2175181

• Allelic Composition: Ntf5^tm1Gdy/Ntf5^tm1Gdy
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased sensory neuron number ( J:25565 )

• homozygotes show a 61% reduction in the number of nodose-petrosal sensory neurons

• however, no reductions in the motor neurons of the facial nucleus or lumbar cord are observed

small petrosal ganglion ( J:25565 )

• homozygotes display an ~61% reduction in nodose-petrosal complex volume and neuronal number relative to wild-type mice

small nodose ganglion ( J:25565 )

• homozygotes display an ~61% reduction in nodose-petrosal complex volume and neuronal number relative to wild-type mice

• however, homozygotes are viable, fertile and behaviorally normal up to 10 months of age, with no apparent deficits in growth or righting responses

• in addition, vestibular, cochlear and trigeminal ganglia are not reduced in size, and brain size is grossly unaffected