Phenotypes Associated with This Genotype

Genotype
MGI:2175178

• Allelic Composition: Ntf3^tm1Lfr/Ntf3^tm1Lfr
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:18984 )

• most die within 24 hours with a few (3 of 300 total) surviving for 7 - 15 days

nervous system

abnormal muscle spindle morphology ( J:132854 )

• fail to form spindles

absent muscle spindles ( J:18984 )

small superior cervical ganglion ( J:18984 )

• at P0, about a 50% decrease in cell number is detected without any increase in pyknotic neurons

small mesencephalic trigeminal nucleus ( J:18984 )

• loss of 56% of sensory neurons

abnormal sensory neuron innervation pattern ( J:18984 )

• group Ia afferents appear to be absent

decreased motor neuron number ( J:132854 )

• small diameter fusimotor axons are absent in the ventral roots of lumbar nerves

• elevated apoptosis of motor neurons between 13.5 and E15.5

abnormal cranial ganglia morphology ( J:18984 )

• loss of 30% of sensory neurons from the petrosal-nodose ganglia

cochlear ganglion hypoplasia ( J:18984 )

• loss of 85% of sensory neurons

small geniculate ganglion ( J:18984 )

• loss of 25% of sensory neurons

small trigeminal ganglion ( J:18984 )

• loss of 61% of sensory neurons

small L5 dorsal root ganglion ( J:18984 )

• loss of 78% of sensory neurons from the L5 ganglion

small dorsal root ganglion ( J:18984 )

• loss of 60 - 80% of neurons

• loss of 62% of sensory neurons from the C1 ganglion

behavior/neurological

abnormal food intake ( J:18984 )

• no evidence of food intake

athetotic walking movements ( J:18984 )

• seen in rare survivors

abnormal limb posture ( J:18984 )

• abnormal limb posture

decreased locomotor activity ( J:18984 )

muscle

abnormal muscle spindle morphology ( J:132854 )

• fail to form spindles

absent muscle spindles ( J:18984 )