Phenotypes Associated with This Genotype

Genotype
MGI:2175177

• Allelic Composition: Ntf3^tm1Jae/Ntf3⁺
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal stellate ganglion morphology ( J:62748 )

• fewer stellate ganglion neurons at P0 and P60 than in wild-type

decreased sensory neuron number ( J:53825 )

• mice exhibit a 17% loss in sensory neurons in the dorsal root ganglion

abnormal dorsal root ganglion morphology ( J:53825 )

• mice exhibit a loss of myelinated fibers in the dorsal root ganglion

cardiovascular system

abnormal cardiovascular system physiology ( J:62748 )

• adults exhibit lower sympathetic tonus than wild-type

decreased heart rate ( J:62748 )

• adults exhibit lower resting heart rates than wild-type

homeostasis/metabolism

abnormal noradrenaline level ( J:62748 )

• 37% decrease in adult heart ventricular norepinephrine concentrations, however no differences seen at birth

muscle

abnormal muscle morphology ( J:53825 , J:23882 )

• muscles exhibit fewer myelinated fibers than in wild-type mice (52+/-4 compared to 76+/-2 in wild-type mice) (J:53825)

• 50% reduction of muscle spindles (J:23882)