Phenotypes Associated with This Genotype

Genotype
MGI:2175176

• Allelic Composition: Ntf3^tm1Jae/Ntf3^tm1Jae
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:23882 )

• by 3 weeks of age

behavior/neurological

ataxia ( J:23882 )

• limb ataxia

impaired limb coordination ( J:23882 )

• display an inability to position the extremities properly when attempting to move

abnormal sensory capabilities/reflexes/nociception ( J:23882 )

• exhibit a tendency of all four limbs to intermittently stiffen in an extensor posture

growth/size/body

decreased body size ( J:23882 )

• retardation

decreased body weight ( J:62748 )

• weigh 20% less than controls at birth

muscle

abnormal muscle morphology ( J:23882 )

absent golgi tendon organ ( J:23882 )

absent muscle spindles ( J:23882 )

• absent muscle spindles

nervous system

absent golgi tendon organ ( J:23882 )

absent muscle spindles ( J:23882 )

• absent muscle spindles

abnormal stellate ganglion morphology ( J:62748 )

• fewer stellate ganglion neurons at P0 and P60 than in heterozygotes or wild-type

small superior cervical ganglion ( J:23882 )

small mesencephalic trigeminal nucleus ( J:23882 )

abnormal innervation pattern to muscle ( J:23882 )

• show no evidence of afferent nerve fiber-muscle contacts

small trigeminal ganglion ( J:23882 )

small nodose ganglion ( J:23882 )

abnormal dorsal root ganglion morphology ( J:23882 )

• loss of carbonic anhydrase (CA) positive neurons, which are mostly L4 dorsal root ganglion neurons

abnormal proprioceptive neuron morphology ( J:23882 )

• central branch of the proprioceptive Ia fibers innvervating spinal cord layer IX is absent

small dorsal root ganglion ( J:23882 )