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Phenotypes Associated with This Genotype
Genotype
MGI:2175152
Allelic
Composition
Nkx3-1tm1Mms/Nkx3-1tm1Mms
Genetic
Background
either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1tm1Mms mutation (3 available); any Nkx3-1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• homozygotes are fertile; however, mutant males exhibit difficulties in forming copulatory plugs with advancing age

endocrine/exocrine glands
• adult homozygotes show a 15-fold reduction in mucin-producing cells and an 11-fold increase in ductal cells relative to wild-type mice
• adult homozygotes show a significant reduction in BUG overall size and wet weight relative to wild-type mice, concomittant with a 15-fold loss of mucin cells
• adult homozygotes often exhibit a transparent anterior prostate relative to the typically opaque wild-type gland
• as early as 4 weeks of age, the mutant anterior prostate displays a multilayered hyperplastic epithelium with relatively normal nuclear morphology
• by 12 weeks, the mutant anterior prostate epithelium exhibits dysplastic regions with variations in nuclear size and shape as well as loss of lumenal space and secretory material
• at 1 year, the mutant anterior prostate shows extensive hyperplastic epithelium with severely dysplastic focal areas but no evidence of tumor formation
• notably, at 1 year, the mutant dorsolateral prostate shows mild hyperplasia and severe dysplasia whereas the ventral prostate remains unaffected
• adult homozygotes exhibit decreased ductal branching without an accompanying reduction in the number, overall size or wet weight of prostatic lobes
• as early as P10-P11, homozygotes show a 60%-75% reduction in ductal tip number relative to wild-type mice
• adult homozygotes exhibit prostate epithelial dysplasia which becomes increasingly severe with advancing age
• by 12 weeks of age, the mutant anterior prostate epithelium displays dysplastic areas with variation in nuclear size and shape as well as aberrant mitotic figures
• at 6 weeks, homozygotes exhibit a 5.8-fold increase in epithelial cell proliferation in the anterior prostate
• adult homozygotes exhibit prostate epithelial hyperplasia which becomes increasingly severe with advancing age
• adult homozygotes show altered secretory protein production, with a new protein species and reduced levels of wild-type secretory proteins
• adult homozygotes show a significant reduction or loss of major prostatic secretory proteins, with a 2.6-fold decrease in total protein concentration of ventral prostate secretions

reproductive system
• adult homozygotes show a 15-fold reduction in mucin-producing cells and an 11-fold increase in ductal cells relative to wild-type mice
• adult homozygotes show a significant reduction in BUG overall size and wet weight relative to wild-type mice, concomittant with a 15-fold loss of mucin cells
• adult homozygotes often exhibit a transparent anterior prostate relative to the typically opaque wild-type gland
• as early as 4 weeks of age, the mutant anterior prostate displays a multilayered hyperplastic epithelium with relatively normal nuclear morphology
• by 12 weeks, the mutant anterior prostate epithelium exhibits dysplastic regions with variations in nuclear size and shape as well as loss of lumenal space and secretory material
• at 1 year, the mutant anterior prostate shows extensive hyperplastic epithelium with severely dysplastic focal areas but no evidence of tumor formation
• notably, at 1 year, the mutant dorsolateral prostate shows mild hyperplasia and severe dysplasia whereas the ventral prostate remains unaffected
• adult homozygotes exhibit decreased ductal branching without an accompanying reduction in the number, overall size or wet weight of prostatic lobes
• as early as P10-P11, homozygotes show a 60%-75% reduction in ductal tip number relative to wild-type mice
• adult homozygotes exhibit prostate epithelial dysplasia which becomes increasingly severe with advancing age
• by 12 weeks of age, the mutant anterior prostate epithelium displays dysplastic areas with variation in nuclear size and shape as well as aberrant mitotic figures
• at 6 weeks, homozygotes exhibit a 5.8-fold increase in epithelial cell proliferation in the anterior prostate
• adult homozygotes exhibit prostate epithelial hyperplasia which becomes increasingly severe with advancing age
• adult homozygotes show altered secretory protein production, with a new protein species and reduced levels of wild-type secretory proteins
• adult homozygotes show a significant reduction or loss of major prostatic secretory proteins, with a 2.6-fold decrease in total protein concentration of ventral prostate secretions

neoplasm
• at 1 year, the mutant anterior prostate shows extensive epithelial hyperplasia and severe dysplasia along with a marked increase in proliferating cells, modeling a preneoplastic condition


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory