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Phenotypes Associated with This Genotype
Genotype
MGI:2175150
Allelic
Composition
Nkx3-1tm1Hha/Nkx3-1tm1Hha
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1tm1Hha mutation (0 available); any Nkx3-1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• homozygotes are developmentally normal and fertile; however, mutant males display inadequate plug formation upon copulation with advancing age

endocrine/exocrine glands
• homozygotes display a marked size reduction in all three minor salivary glands, with smaller apical mucous end-pieces relative to wild-type mice
• the mutant palatine gland is significantly smaller; similar size reductions are noted in the glandula lingualis and glandula buccalis
• in addition, the ductal system exhibits irregular branching esp. in the glandula palatina and glandula lingualis
• in homozygotes, the ducts of minor salivary glands appear smaller in diameter and the diameter of the ductal lumen is reduced by thicker epithelium
• smaller ducts with reduced internal lumens are particularly pronounced in the palatine and lingual glands
• adult homozygotes show evidence for salivary gland epithelial hyperplasia, although not as severe as in the prostate
• homozygotes exhibit significantly smaller minor salivary glands (i.e. glandula buccalis, glandula palatina, and glandula lingualis) relative to wild-type mice
• unlike wild-type mice, homozygotes frequently contain relatively dry food residues in their mouths, suggesting impaired mucous salivary production
• at 4 months, mutant BUGs exhibit an increased number of nuclei, suggesting hyperproliferation of epithelial cells
• at 4 months, mutant BUGs show a dramatic reduction of mucin-producing cells and contain primarily ductal cells, suggesting abnormal cell differentiation or an imbalance in cell growth
• at 3 months, homozygotes exhibit a significantly smaller bulbourethral glands (BUGs) relative to wild-type mice
• homozygotes invariably display prostate epithelial hyperplasia in the absence of overt prostate tumors during the observation period of >1 year
• at 3 months, homozygotes exhibit a moderate size reduction of the anterior prostate
• at 3 months, homozygotes exhibit fewer but enlarged prostatic ducts in the anterior prostate and other prostatic lobes
• although adult homozygotes exhibit all three prostatic lobes, the number of prostatic ducts appears reduced relative to heterozygous and wild-type mice
• in addition, individual ducts appear enlarged, suggesting defective ductal branching
• adult homozygotes show progressive dysplastic changes in the duct epithelium of the anterior and dorsolateral prostate, resulting in a severely dysplastic, multi-layered epithelium with little secreted fluid in the duct lumen at 10 months
• as early as 2 months, homozygotes exhibit progressive prostate epithelial hyperplasia in the anterior and dorsolateral lobes; however, no hyperplasia is noted in ventral prostatic lobes

reproductive system
• at 4 months, mutant BUGs exhibit an increased number of nuclei, suggesting hyperproliferation of epithelial cells
• at 4 months, mutant BUGs show a dramatic reduction of mucin-producing cells and contain primarily ductal cells, suggesting abnormal cell differentiation or an imbalance in cell growth
• at 3 months, homozygotes exhibit a significantly smaller bulbourethral glands (BUGs) relative to wild-type mice
• homozygotes invariably display prostate epithelial hyperplasia in the absence of overt prostate tumors during the observation period of >1 year
• at 3 months, homozygotes exhibit a moderate size reduction of the anterior prostate
• at 3 months, homozygotes exhibit fewer but enlarged prostatic ducts in the anterior prostate and other prostatic lobes
• although adult homozygotes exhibit all three prostatic lobes, the number of prostatic ducts appears reduced relative to heterozygous and wild-type mice
• in addition, individual ducts appear enlarged, suggesting defective ductal branching
• adult homozygotes show progressive dysplastic changes in the duct epithelium of the anterior and dorsolateral prostate, resulting in a severely dysplastic, multi-layered epithelium with little secreted fluid in the duct lumen at 10 months
• as early as 2 months, homozygotes exhibit progressive prostate epithelial hyperplasia in the anterior and dorsolateral lobes; however, no hyperplasia is noted in ventral prostatic lobes

digestive/alimentary system
• homozygotes display a marked size reduction in all three minor salivary glands, with smaller apical mucous end-pieces relative to wild-type mice
• the mutant palatine gland is significantly smaller; similar size reductions are noted in the glandula lingualis and glandula buccalis
• in addition, the ductal system exhibits irregular branching esp. in the glandula palatina and glandula lingualis
• in homozygotes, the ducts of minor salivary glands appear smaller in diameter and the diameter of the ductal lumen is reduced by thicker epithelium
• smaller ducts with reduced internal lumens are particularly pronounced in the palatine and lingual glands
• adult homozygotes show evidence for salivary gland epithelial hyperplasia, although not as severe as in the prostate
• homozygotes exhibit significantly smaller minor salivary glands (i.e. glandula buccalis, glandula palatina, and glandula lingualis) relative to wild-type mice
• unlike wild-type mice, homozygotes frequently contain relatively dry food residues in their mouths, suggesting impaired mucous salivary production

cellular
• in mutant glandula palatina and glandula lingualis, the epithelium appears significantly thicker, suggesting epithelial hyperproliferation

embryo
N
• surpisingly, homozygotes exhibit no sclerotomal defects and develop into adulthood with no apparent skeletal abnormalities

homeostasis/metabolism
• unlike wild-type mice, homozygotes frequently contain relatively dry food residues in their mouths, suggesting impaired mucous salivary production


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory